منابع مشابه
Genetic linkage analysis.
Genetic linkage analysis is a powerful tool to detect the chromosomal location of disease genes. It is based on the observation that genes that reside physically close on a chromosome remain linked during meiosis. For most neurologic diseases for which the underlying biochemical defect was not known, the identification of the chromosomal location of the disease gene was the first step in its ev...
متن کاملGenetic Linkage Analysis
IIIStatistical properties of the method of lod scores III1. The test procedure III1.1. Impact of non-sequentiality III1.2. Maximization of the lod score over the [0, 1/2] interval III1.3 References III-2. Genotype information III-2.1. Ambiguity in phenotype-genotype relationships at the disease locus III-2.2. Ambiguity in the marker genotype III-2.3. Gamete disequilibrium between alleles at the...
متن کاملnon-parametric methods in genetic linkage analysis
one of the most important goals for researchers in the clinic is to try to find newer and more effective ways to diagnose and cure the diseases. these clinical advances can create new points of view in other sciences and their combination with basic sciences such as statistics can improve these researches. in statistical genetics, linkage analysis is a way of finding the exact locus of a diseas...
متن کامل1953: An unrecognized summit in human genetic linkage analysis
This paper summarizes and discusses the methodological research in human genetic linkage analysis, leading up to and following from the paper of C. A. B. Smith presented as a Royal Statistical Society discussion paper in 1953. This paper was given as the Fisher XXVII Memorial Lecture, in Cambridge, December 4, 2006. AMS 2000 subject classifications: Primary 62-03; secondary 01A60.
متن کاملResultants in genetic linkage analysis
Statistical models for genetic linkage analysis of k locus diseases are k-dimensional subvarieties of a (3 − 1)-dimensional probability simplex. We determine the algebraic invariants of these models with general characteristics for k = 1, in particular we recover, and generalize, the Hardy-Weinberg curve. For k = 2, the algebraic invariants are presented as determinants of 32 × 32-matrices of l...
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ژورنال
عنوان ژورنال: Journal of Medical Genetics
سال: 1992
ISSN: 1468-6244
DOI: 10.1136/jmg.29.9.680